Current Research

Braden, K.; Campolo, M.; Li, Y.; Chen, Z.; Doyle, T.; Giancotti, L.; Esposito, E.; Zhang, J.; Cuzzocrea, S.; Arnatt, C. K.; Salvemini, D. Activation of GPR183 by 7α,25-dihydroxycholesterol induces behavioral hypersensitivity through MAPK and NF-κB. Journal of Pharmacology and Experimental Therapeutics, 2022, in press.

Squillace, S.; Niehoff, M.; Doyle, T. M.; Green, M.; Esposito, E.; Cuzzocrea, S.; Arnatt, C. K.; Spiegel, S.; Farr, S.; Salvemini, D. Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairments. Journal of Clinical Investigation, 2022, in press.

Agongo, J.; Armbruster, M.; Arnatt, C. K.; Edwards, J. Analysis of endogenous metabolites using multifunctional derivatization and capillary RPLC-MS. Analytical Methods, 2022, in press.

Pemberton, K.; Rosato, M.; Dedert, C.; DeLeon, C.; Arnatt, C. K.; Xu, F. Differential effects of the G protein-coupled estrogen receptor (GPER) on rat embryonic (E18) hippocampal and cortical neurons. eNeuro, 2022, in press.

DeLeon, C.; Pemberton, K.; Green, M.; Kalajdzic, V.; Rosato, M.; Xu, F.; Arnatt, C. K. Novel GPER agonist, CIFTA, increases neurite growth in rat embryonic (E18) hippocampal neurons. ACS Chemical Neuroscience, 2022, 13, 1119-1128.

Armbruster, M.; Grady, S.; Agongo, J.; Arnatt, C. K.; Edwards, J. L. Neutron encoded derivatization of endothelial cell lysates for quantification of aldehyde metabolites using nESI-LC-HRMS. Analytica Chimica Acta 2022, 1190, 339260.

Armbruster, M. R.; Grady, S. F.; Arnatt, C. K.; Edwards, J. L. Isobaric 4-plex tagging for absolute quantitation of biological acids in diabetic urine using capillary LC-MS/MS. ACS Measurement Science Au 2022, 2, 287-295.

Armbruster, M.; Grady, S.; Agongo, J.; Arnatt, C. K.; Edwards, J. L. Neutron encoded derivatization of endothelial cell lysates for quantification of aldehyde metabolites using nESI-LC-HRMS 2021, 1190, 339260.

Isor, A.; O’Dea, A. T.; Grady, S. F.; Petroff, J. T.; Skubic, K. N.; Aziz, B.; Arnatt, C. K.; McCulla, R. D. Effects of photodeoxygenation on cell biology using dibenzothiophene S-oxide derivatives as O(3P)-precursors. Photochemical & Photobiological Sciences 2021, 20, 1621-1633.

Grady, S. F.; Pinto, A. K.; Hassert, M.; D’Angelo, J. A.; Brien, J. D.; Arnatt, C. K. Selective estrogen receptor modulator, tamoxifen, inhibits Zika virus infection. Journal of Medical Virology 2021, 93, 6155-6162.

Lu, A. S.; Rouhimoghadam, M.; Arnatt, C. K.; Filardo, F. J.; Salem, A. K. Proteolytic Targeting Chimeras with Specificity for Plasma Membrane and Intracellular Estrogen Receptors. Molecular Pharmaceutics 2021, 18, 1455-1469.

DeLeon, C.; Wang, D. Q.-H.; Arnatt, C. K. G Protein-Coupled Estrogen Receptor, GPER1, Offers a Novel Target for the Treatment of Digestive Diseases. Frontiers in Endocrinology 2020, 11, 843-848.

Isor, A.; O’Dea, A. T.; Petroff, J. T.; Skubic, K. N.; Grady, S. F.; Arnatt, C. K.; McCulla, R. D. Synthesis of triphenylphosphonium dibenzothiophene S-oxide derivatives and their effect on cell cycle as photodeoxygenation-based cytotoxic agents. Bioorganic Chemistry 2020, 105, 104442.

Braden, K.; Giancotti, L. A.; Chen, Z.; DeLeon, C.; Latzo, N.; Boehm, T.; D’Cunha, N.; Thompson, B. M.; Doyle. T. M.; McDonald, J. G.; Walker, J. K.; Kolar, G. R.; Arnatt, C. K.; Salvemini, D. GPR183-oxysterol axis in spinal cord contributes to neuropathic pain. Journal of Pharmacology and Experimental Therapeutics 2020, DOI: https://doi.org/10.1124/jpet.120.000105. *Featured cover article

Petroff, J. T.; Isor, A.; Chintala, S. M.; Albert, C. J.; Franke, J. D.; Weinstein, D.; Omlid, S. M.; Arnatt, C. K.; Ford, D. A.; McCulla, R. D. In vitro oxidations of low-density lipoprotein and RAW 264.7 cells with lipophilic O(3P)-precursors. RSC Advances 2020, 10, 26553-26565.

DeLeon, C.; Wang, H. H.; Gunn, J.; Wilhelm, M.; Cole, A.; Arnett, S.; Wang, D. Q.-H.; Arnatt, C. K. A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice. Journal of Lipid Research 2020, 61, 767-777.

Wang, H. H.; Bari, O. D.; Arnatt, C. K.; Liu, M.; Portincasa, P.; Wang, D. Q.-H. Activation of a novel estrogen receptor GPR30 enhances cholesterol cholelithogenesis in female mice. Hepatology 2020, doi:10.1002/hep.31212.

Petroff, J. T.; Grady, S.; Arnatt, C. K.; McCulla, R. D. Dibenzothiophene sulfone derivatives as plasma membrane dyes. Photochemistry and Photobiology 2020, 96 67-73.

O’Dea, A.; Sondergard, C.; Sweeney, P.; Arnatt, C. K. A series of indole-thiazole derivatives act as GPER agonists and inhibit breast cancer cell growth. ACS Medicinal Chemistry Letters 2018, 9, 901-906.

Petroff, J. T.; Skubic, K. N. Arnatt, C. K.; McCulla, R. D. Asymmetric Dibenzothiophene Sulfones as Fluorescent Nuclear Stains. Journal of Organic Chemistry 2018, 83, 14063-14068.

Patents

Petroff, J.T.; McCulla, R. D.; Arnatt, C. K. Dibenzothiophene compounds, 2018, US patent US10221153B2.

Arnatt, C. K.; Elliott, J. T. Process for making an asymmetric fluorophore, 2018, US patent 9951271.

Previous Research

Arnatt, C. K.; Falls, B. A.; Yuan, Y.; Raborg, T. J.; Masvekar, R. R.; El-Hage, N.; Selley, D. E.; Nicola, A. V.; Knapp, P. E.; Hauser, K. F.; Zhang, Y. Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization. Bioorganic & Medicinal Chemistry 2016, 24, 5969-5987.

Yuan, Y.; Li, X.; Zaidi, S. A.; Arnatt, C. K.; Yu, X.; Guo, C.; Wang, X. Y.; Zhang, Y. Small molecule inhibits activity of scavenger receptor A: Lead identification and preliminary studies. Bioorganic & Medicinal Chemistry Letters 2015, 25, 3179-3183.

Arnatt, C. K.; Zhang, Y. Bivalent ligands targeting chemokine receptor dimerization: Molecular design and functional studies. Current Topics in Medicinal Chemistry 2014, 14, 1606.

Arnatt, C. K.; Adams, J. L.; Zhang, Z.; Haney, K. M.; Guo, Li, Zhang, Y. Design, synthesis, and characterization of piperazine based chemokine receptor CCR5 antagonists as anti prostate cancer agents. Bioorganic & Medicinal Chemistry Letters 2014, 24, 2319-2323.

Zaidi, S. A.; Arnatt, C. K.; He, H.; Selley, D. E.; Mosier, P. E.; Kellogg, G. E.; Zhang, Y. Binding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: Application of the ‘message-address’ concept in development of mu opioid receptor selective antagonists. Bioorganic & Medicinal Chemistry, 2013, 21, 6405-6413.

Arnatt, C. K.; Zaidi, S. A.; Zhang, Z.; Li, G.; Richardson, A. C.; Ware, J. L.; Zhang, Y. Design, synthesis, and characterization of pharmacophore based chemokine receptor CCR5 antagonists as anti prostate cancer agents. European Journal of Medicinal Chemistry, 2013, 69, 647-658.

El-Hage, N.; Dever, S. M.; Podhaizer, E. M.; Arnatt, C. K.; Zhang, Y.; Hauser, K. F. A novel bivalent HIV-1 entry inhibitor reveals fundamental differences in CCR5-µ-opioid receptor interactions between human astroglia and microglia. AIDS 2013, 27, 2181-2190.

Arnatt, C. K.; Zhang, Y. G protein-coupled estrogen receptor (GPER) agonist dual binding mode analyses toward understanding of its activation mechanism: a comparative homology modeling approach. Molecular Informatics 2013, 32, 647-658.

Yuan, Y.; Arnatt, C. K.; El-Hage, N.; Dever, S.; Jacob, J.; Selley, D.; Hauser, K.; Zhang, Y. A bivalent ligand targeting the putative mu opioid receptor and chemokine receptor CCR5 heterodimers: binding affinity versus functional activities. Med. Chem. Comm.  2013, 4, 847-851.

Arnatt, C. K.; Zhang, Y. A nuclear G protein-coupled estrogen receptor, GPER. Homology modeling studies toward its ligand-binding mode characterization. In Computational Approaches to Nuclear Receptors; Cozzini, R.; Kellogg, G. E., Eds.; The Royal Society of Chemistry, London, U.K., 2012; pp 117-137.

Zhang, F.; Arnatt, C. K.; Haney, K. M.; Fang, H. C.; Bajacan, J. E.; Richardson, A. C.; Ware, J. L.; Zhang, Y. Structure activity relationship studies of natural product chemokine receptor CCR5 antagonist anibamine toward the development of novel anti prostate cancer agents. European Journal of Medicinal Chemistry 2012, 55, 395-408.

Zhang, Y.; Arnatt, C. K.; Zhang, F.; Wang, J.; Haney, K. M.; Fang, X. The potential role of anibamine, a natural product CCR5 antagonist, and its analogues as leads toward development of anti-ovarian cancer agents. Bioorganic & Medicinal Chemistry Letters 2012, 22, 5093-5097.

Yuan, Y.; Arnatt, C. K.; Li, G.; Haney, K. M.; Ding, D.; Jacob, J. C.; Selley, D. E.; Zhang, Y. Design and synthesis of a ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5. Organic & Biomolecular Chemistry 2012, 10, 2633-2646.

Arnatt, C. K.; Zhang, Y. Facile synthesis of 2,3,5,6-tetrabromo-4-methyl-nitrocyclohexa- 2,5-dien-1-one, a mild nitration reagent. Tetrahedron Letters 2012, 53, 1592-1594.

Haney, K. M.; Zhang, F.; Arnatt, C. K.; Yuan, Y.; Li, G.; Ware, J. L.; Gerwirtz, D. A.; Zhang, Y. The natural product CCR5 antagonist anibamine and its analogs as antiprostate cancer agents. Bioorganic & Medicinal Chemistry Letters 2011, 21, 5159-63.